|“||Spring...The day I've been waiting for has finally arrived! Today I will take my first steps as an investigator! From today on, I'm assigned to the Special Investigations Department. My name is Misaki Asano!||”|
–Misaki Asano, Danganronpa Gaiden: Killer Killer
Misaki is a member of Future Foundation and is an investigator working for the 6th Division’s Special Case Bureau. Her partner is Takumi Hijirihara, a famous serial killer who has nicknamed as Killer Killer.
Misaki was impaled and injured by Shuji Fujigawa in chapter 9 as an attempt to make Takumi understand the horror of murders. As from chapter 10, she was freed from Shuji but he left a strange metallic thing set on around Misaki's neck with an unknown function.
Misaki is a petite woman with a determined expression. She has blonde hair styled held back by a black headband with a red streak going through it and large gray eyes. She wears a standard Future Foundation uniform consisting of a white dress shirt, black jacket, red tie, black skirt and shoes.
Despite being a special investigator for bizarre murder cases, she states that she hates gore. Her determination and optimism help her persevere through this, alongside her cooperation with Takumi. While she can be easily angered by him, she is also shown to be compassionate and patient when it comes to trying to understand his motivation.
Chapter 1 - Murder for Murder
Misaki is first seen inside Ikue Dogami's office being briefed for her first day on the job. Her dream to become a special investigator finally came true. After Chief Dogami tells Misaki to use any free locker, Misaki found her new partner, Takumi Hijirihara inside a locker making her freak out. The chief informs her that Takumi will be her partner from now on, and several coworkers express how badly they feel for the newbie to be stuck with Takumi of all people.
Chief Dogami immediately gives Misaki and Takumi a new case where a threatening letter was sent to a "Monk Idol", Momomichi Ito in the form of a grotesque 4-koma. Their task is to oversee the idol's security. Misaki is determined to make a fantastic first impression, while Takumi lazily attempts to excuse himself.
Arriving at the scene, Misaki discovers Takumi in the shrine's offering box and bickers with him. After ordering the rest of her team to secure the area, she meets with Yoshihiko Ayashi. Yoshihiko explains that a cult group have been spying on the Monk Idol in his many previous events. On the stage, Misaki sees three Asura statues and wondered if they were placed as the background.
As the concert started, Misaki enjoys Momomichi's sing until the Asura statues revealed as crafted corpses. She and her team immediately open the investigation and evacuate all guests from the crime scene. Misaki watches confused as Takumi wakes up and angrily approaches the crime scene. This turns to astonishment when Takumi hugs one of the corpses' legs and mumbles to himself. After a period of investigation, Misaki finally reached the conclusion that the culprit is the one who sent the threat letter and after committing his crime, he fled from the scene--though Takumi immediately corrects her, telling Misaki that the culprit was still in the vicinity. The two continue to bicker then Takumi leaves the scene to allow Misaki to handle the situation herself, which angers her.
After returning to HQ, Misaki confides in Chief Dogami about her frustrations in dealing with Takumi. After a short time, Chief Dogami reminds her of a school massacre that had happened several years ago. Misaki recalls hearing about it, and how much it shocked her because the victims of the massacre were all children her age. Chief Dogami tells her that Takumi is the sole survivor of that incident, and as a result has developed several strange habits stemming from the psychological trauma.
Chief Dogami and Misaki return to the crime scene only to discover the true killer, Momoichi Ito, as nothing more than a pile of powder. Rather than be disgusted, Misaki is amazed. The two find the note left by Killer Killer and return back to HQ. Later, Misaki finds Takumi underneath the counter in the break room and makes a resolution to try and understand him. She joins him underneath the counter and, to her surprise, finds it comfortable.
Chapter 2 - Symbiotic Hospital
Misaki is first shown drinking coffee at the start of her day, when Takumi pops up from under the sink, hitting Misaki's legs with the door. After Takumi comments on seeing her panties, Misaki storms off until she runs into Takumi, holding a child. Misaki gets slightly concerned until; she recognizes the child as Mekuru Katsuragi. After commenting on the two's relationships, Chief Dogami sends them on another mission.
Arrived at Ongou Hospital, Misaki and Takumi entered a patient room, the crime scene. The victim was Hana Niyama, gruesomely murdered on her bed. Misaki wondered if Takumi went mad again, but instead he hugged the victim's body. Misaki shouted at him after he fell asleep beside the body. After Misaki and the investigators discovered a scalpel on the culprit's stomach, Misaki decided to interrogate some doctors from the hospital.
Chapter 3 - Bessatsu Shounen Zetsubou Magazine
Misaki is shown very briefly in the back of a van after being kidnapped by Juzo Sakakura (posing as Ted Chikatilo.) She and Mekuru were captured and taken as hostages in order to lure Takumi to the Tify Ariake Arena. Misaki squirms to try and get herself free, but quickly notices a third person in the van. She looks on in horror as she appears to see Makoto Naegi's stiff body, face-up.
Chapter 4 - Sting Casino Murders
Misaki is shown being carried to unknown room while tied and blindfolded by Juzo. After her blindfold falls off she realizes that she is sitting on a chair, tied. She then remembers that Mekuru was also tied and carried away. Before she can do anything she hears the voice from the vents and realizes that she is in the Festival of Murder, a serial killer gambling game. While listening, she finds out that Juzo just blew up Makoto's body and that he will be fighting against Takumi, who came there to save Misaki and Mekuru. Through out the fight Misaki starts panicking, realizing that Takumi will most likely die. Juzo then reveals that Takumi is the Killer Killer. Before Juzo can blow Takumi up, the real Ted appears, accidentally blowing up the side of Misaki's room, giving her the ability to escape and see what's going on.
Chapter 5 - Firework Lyric
Misaki was in great shocked after she learned that Juzo disguised as Ted upon the real serial killer arrived in the Killing Festival. At first, she doubted that Juzo will survive the crowds' attack but soon changed her mind after she recalled that Juzo has a reputation as the most terrifying Future Foundation's member.
After Juzo with his special troops and Ted defeated most of the crowds, Misaki stumbled upon a hanging corpse belong to The Republic of Lamieca's Secretary of Defense. After the quick investigation, Misaki worried about Takumi's condition.
Chapter 6 - Possibility of Despair
Chapter 7 - Pre-Wedding Mystery Tour
At the beginning of the chapter, Misaki was shown relaxing by herself in a calm and quite hot spring. Unfortunately, she came to the hot spring in a not perfect time as Kinari Kunugida, an underground gravure idol also paid a visit along with her noisy fan club. Due to this, Misaki regretted her decision in agreeing to visit the hot spring.
Chapter 8 - Beginning of Killer Killer
Chapter 9 - Don't Kill
Misaki was still in disbelief to hear about Takumi being the Killer Killer. As she watched him depart to find Mukuro Ikusaba, she attempted to stop him and question him about his real identity, but she obtained no answer.
She followed Takumi to the destination building along with Shuji, horrified to find the entirety of Future Foundation's 8th Branch's Security having been murdered as soon as they stepped in. Mukuro appeared a few seconds after, rushing for Misaki and trying to murder her, but she was stopped by Takumi and the two began a fight.
She watched as Takumi showed real intent to murder Mukuro with a mortified expression, still trying to cling on to the thought that he isn't the Killer Killer. However, she, along with Shuji, are surrounded by multiple Mukuro lookalikes which are quickly defeated by Takumi. As she incapacitated the remaining ones using a gun filled with muscle relaxants, she tried to convince Takumi one last time to tackle the issue without any murders happening, but she was not listened to and she witnessed him murdering the remaining clones with a mortified expression. She finally accepted the fact that Takumi is the Killer Killer, breaking into tears.
However, she was then impaled through the chest by Shuji, using a dagger, who attempted to use this as a last resort to bring Takumi back to his senses and make him stop murdering.
Chapter 10 - Killer Killer Killer
Misaki was threatened by Shuji who grabbed Misaki's hair and lay his knife on her neck. If Takumi swore to stop being the Killer Killer, then Misk will be freed.
Later, Shuji is forced to flee due to intervention by Future Foundation staff members Juzo, Sonosuke Izayoi, Ruruka Ando, Ikue and other members. It is revealed by the end of the chapter that she has something metallic on her neck.
Misaki has a difficult time trying to understand Takumi and his odd behaviors, and often gets frustrated with him as a result. However, she continues to make an effort to understand him, even if she herself finds his habits and personality to be sloppy. Her concern for him is shown when she takes Takumi's invitation to hide underneath the sink with him and waiting in his hospital room for him to wake up.
Misaki has enormous difficulty believing that Takumi is the Killer Killer at first, having seen him in an entirely different light during all the time she spent with him. However, she has no other choice but accept the reality of things as she witnessed Takumi's Killer Killer persona in action as he faced and murdered the numerous Mukuro lookalikes. She was sad at first knowing that his true identity as the Killer Killer. However, Misaki understands that he turned himself as a serial killer who kills serial killers after he experienced a deadly experience such as Giboura Massacre.
Misaki sees Ikue as her superior, and listens to all her orders no matter what. The two seem to get along well.